The San Francisco 49ers host the Tennessee Titans in a Week 15 matchup that effectively closes out the easier portion of their 2025-26 regular season schedule. They travel to face a struggling Indianapolis Colts squad next week, but the Titans close out a clearly cake stretch that included games against the Cardinals, Panthers, and Browns.
The 49ers are coming off their bye and are double digit favorites against the Titans. Plenty can happen on any given Sunday, but nobody expects the 49ers to lose this game. They’ve lost a lot of players to injury this year, but the players that are healthy are coming into this game with extra rest.
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