Week 12 of the 2025 NFL season wraps up tonight with a showdown featuring the Carolina Panthers visiting the San Francisco 49ers. San Francisco enters as a 7.5-point home favorite, with an over/under of 49.5. With the Buccaneers getting blown out by the Rams on Sunday, the Panthers could jump into first place in the NFC South with a win tonight. Meanwhile, the Niners are currently clinging on to the final NFC Wild Card spot and they would stay afloat in the playoff hunt with a victory here.
Below, we will take a look at the best DFS plays for this Monday night showdown.
Captain’s Picks
Christian McCaffrey, RB, San Francisco 49ers
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