The San Francisco 49ers close out the 2025-26 regular season with a matchup for all the marbles against the Seattle Seahawks. The division title and No. 1 seed in the NFC conference are on the line, which marks the second such season finale circumstances since 2019. In 2019, the 49ers won that game 26-21, securing the victory with a fourth and goal stop in the closing seconds.
That year, the 49ers entered the game with a one game lead over the Seahawks. This year, Seattle has the one-game lead. Seattle is a 1.5-point road favorite in this matchup.
San Francisco 49ers playoff clinching scenarios
The 49ers have a simple clinching scenario. If
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